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Management of Systemic Lupus Erythematosus (SLE)


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    Overview and Recommendations

    • Background

    • Evaluation

    • Management

    • Disease Activity Monitoring and Follow-up

  • Related Summaries

  • Definitions

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    Considerations before Initiating Treatment

    • General considerations

    • Screening and baseline testing prior to treatment initiation

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    Approach to Management

    • Treat-to-target

    • European League Against Rheumatism (EULAR) 2019 recommendations for the management of SLE

    • Neuropsychiatric SLE (NPSLE)

    • Lupus nephritis (LN)

    • Cutaneous lupus erythematosus (CLE)

    • Management of SLE during pregnancy

    • Management of antiphospholipid antibodies in SLE

  • Disease Activity Indices and Outcome Measures

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    • Antimalarials

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      • General information

      • Efficacy

      • Safety and adverse events

    • Nonsteroidal anti-inflammatory drugs (NSAIDs)

    • Immunosuppressive agents

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      Biologics and small molecules

      • European League Against Rheumatism (EULAR) recommendations on use of biologics for management of SLE

      • Belimumab

      • Rituximab

      • Other biologics under investigation

    • Androgenic therapy

    • Other medications

  • Stem Cell Transplantation

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    Adjunct and Nonpharmacologic Therapy

    • Diet

    • Activity

    • Counseling

    • Other therapies

  • Other Considerations for Medication Use in Patients with SLE

  • Immunizations

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    • Recommendations on laboratory testing and other monitoring

    • Monitoring for drug toxicity

    • Monitoring for comorbidities

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    Guidelines and Resources

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      • International guidelines

      • United States guidelines

      • United Kingdom guidelines

      • Canadian guidelines

      • European guidelines

      • Asian guidelines

      • Central and South American guidelines

    • Review articles

    • MEDLINE search

  • Patient Information

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    ICD Codes

    • ICD-10 codes

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    • General references used

    • Recommendation grading systems used

    • Synthesized Recommendation Grading System for DynaMed

    • DynaMed Editorial Process

    • Special acknowledgements

    • How to cite

Topic Editor
Jefferson R. Roberts MD

Assistant Clinical Professor, University of Hawaii, John A. Burns School of Medicine; Hawaii, United States; Chief of Rheumatology Service and Chief of Medical Simulation, Tripler Army Medical Center; Hawaii, United States

Conflicts of Interest

Dr. Roberts declares no relevant financial conflicts of interest.

Recommendations Editor
Esther Jolanda van Zuuren MD

Head of Allergy, Dermatology, and Venereology, Leiden University Medical Centre; Netherlands

Conflicts of Interest

Dr. van Zuuren declares no relevant financial conflicts of interest.

Deputy Editor
Vito Iacoviello MD, FIDSA

Deputy Editor of Infectious Diseases, Immunology and Rheumatology, Dynamed; Massachusetts, United States; Assistant Professor of Medicine, Harvard Medical School; Massachusetts, United States; Chief of the Division of Infectious Diseases, Mount Auburn Hospital; Massachusetts, United States

Conflicts of Interest

Dr. Iacoviello declares no relevant financial conflicts of interest.