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Statins for Primary and Secondary Prevention of Cardiovascular Disease


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    Overview and Recommendations

    • Background

    • Evaluation

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      • Primary prevention

      • Secondary prevention

      • Blood test monitoring for statin users

  • Related Summaries

  • Overview

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      United States recommendations

      • American College of Cardiology/American Heart Association (ACC/AHA) Task Force on Clinical Practice Guidelines - 2018 cholesterol clinical practice guidelines

      • United States Preventive Services Task Force (USPSTF) recommendations

      • Comparison of USPSTF and ACC/AHA recommendations

    • United Kingdom recommendations

    • European Society of Cardiology/European Atherosclerosis Society recommendations

    • Canadian Cardiovascular Society guidelines

  • Efficacy Across Populations

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    Patients with Cardiovascular Disease (Secondary Prevention)

    • Systematic reviews

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      Comparisons of dose intensity

      • High-dose vs. low-dose statins

      • Atorvastatin 80 mg vs. atorvastatin 10 mg

      • Atorvastatin 80 mg vs. pravastatin 40 mg

      • Atorvastatin 80 mg vs. simvastatin 20 mg

      • Rosuvastatin 40 mg vs. atorvastatin 80 mg

      • Simvastatin 80 mg vs. simvastatin 20 mg

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      Selected randomized placebo-controlled trials

      • Pravastatin trials

      • Simvastatin trials

      • Other statin trials

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    Primary Prevention of Heart Disease

    • Efficacy for primary prevention

    • Efficacy in patients with low or normal cholesterol levels

  • Women

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    • Statin Recommendations for Elderly Patients from Professional organizations

    • Evidence for Statins in Elderly Patients

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    Other Specific Populations

    • Children and adolescents

    • Asian patients

    • Patients with diabetes

    • Patients with familial hypercholesterolemia (FH)

    • Patients with heart failure

    • Heart transplant recipients

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      Patients with chronic kidney disease

      • Statins in chronic kidney disease (CKD) patients not on dialysis

      • Statins in dialysis patients

      • Statins in renal transplant recipients

      • Reviews of statins in renal disease

    • High cholesterol absorbers

    • Patients with abnormal liver function test

    • Patients with life-limiting illness

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    Prevention of Stroke

    • Statins for primary prevention of stroke

    • Statins for secondary prevention of stroke

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    Comparative Efficacy

    • Comparative efficacy for clinical outcomes

    • Comparative efficacy for lipid levels

  • Adverse effects of statins

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    Guidelines and Resources

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      • United States guidelines

      • United Kingdom guidelines

      • Canadian guidelines

      • European guidelines

    • Review articles

  • Patient Decision Aids

  • Patient Information

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    Quality Improvement

    • Physician Quality Reporting System Quality Measures

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    • General references used

    • Recommendation grading systems used

    • Synthesized Recommendation Grading System for DynaMed

    • DynaMed Editorial Process

    • Special acknowledgements

    • How to cite

Topic Editor
Lavanya Bellumkonda MD

Assistant Professor in Medicine and Associate Medical Director, Center for Advanced Heart Failure, Yale University School of Medicine; Connecticut, United States; Medical Director, Verdi 5 East, Yale New Haven Hospital; Connecticut, United States

Recommendations Editor
Zbys Fedorowicz MSc, DPH, BDS, LDSRCS

Director of Bahrain Branch of the United Kingdom Cochrane Center, The Cochrane Collaboration; Awali, Bahrain

Conflicts of Interest

Dr. Fedorowicz declares no relevant financial conflicts of interest.

Deputy Editor
Peter Oettgen MD

Editor in Chief, DynaMed; Cardiologist, Beth Israel Deaconess Medical Center; Massachusetts, United States; Associate Professor of Medicine, Harvard Medical School; Massachusetts, United States

Conflicts of Interest

Dr. Oettgen declares no relevant financial conflicts of interest.