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Osteomyelitis

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General Information

Description

  • bacterial or fungal infection of bone1,2
  • may present as acute infection or chronic infection1,2
  • most common infecting organism is Staphylococcus aureus1,2

Definitions

  • acute osteomyelitis defined as absence of necrotic bone1,2
    • more common in children with hematogenous seeding of metaphysis (growing regions) of long bones
    • symptoms generally develop within 2 weeks of infection, including fever and pain and swelling at involved bones
  • subacute osteomyelitis defined as low-grade bone infection usually with lack of systemic manifestations
    • onset insidious
    • Brodie abscess is localized bone abscess
      • subacute cases present with fever, pain, and periosteal elevation
      • distal part of tibia most commonly involved
      • about 75% of cases occur in adults ≤ 25 years old
    • Reference - 2, Orthopedics 1990 Mar;13(3):363OpenInNew
  • chronic osteomyelitis defined as presence of necrotic bone1,2
    • more common in adults
    • patients typically have history of osteomyelitis and present recurrent pain, erythema, and swelling associated with draining sinus

Types

  • classification systems for osteomyelitis
    • Lew and Waldvogel classification system based on duration and mechanism of infection
    • Cierny-Mader staging system (useful for patient evaluation and treatment planning)
      • anatomic type
        • stage 1 - medullary osteomyelitis
        • stage 2 - superficial osteomyelitis
        • stage 3 - localized osteomyelitis
        • stage 4 - diffuse osteomyelitis
      • physiologic class
        • A host - normal host
        • B host - systemic compromise (Bs), local compromise (Bl), systemic and local compromise (Bls)
        • C host - treatment worse than disease
      • risk factors that affect immune surveillance, metabolism, and local vascularity
        • systemic factors (Bs)
          • malnutrition
          • renal or hepatic failure
          • diabetes mellitus
          • chronic hypoxia
          • immune disease or immunosuppression
          • malignancy
          • extremes of age
        • local factors (Bl)
          • chronic lymphedema
          • major vessel compromise
          • small vessel disease
          • vasculitis
          • venous stasis
          • extensive scarring
          • radiation fibrosis
          • neuropathy
          • tobacco abuse
      • Reference - 12966271Clin Orthop Relat Res 2003 Sep;(414):7OpenInNew

References

General References Used

  1. Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011 Nov 1;84(9):1027-33OpenInNewfull-textOpenInNew, commentary can be found in Am Fam Physician 2012 Nov 15;86(10):888OpenInNew
  2. Calhoun JH, Manring MM. Adult osteomyelitis. Infect Dis Clin North Am. 2005 Dec;19(4):765-86OpenInNew
  3. Hogan A, Heppert VG, Suda AJ. Osteomyelitis. Arch Orthop Trauma Surg. 2013 Sep;133(9):1183-96OpenInNew

Recommendation Grading Systems Used

  • Infectious Diseases Society of America (IDSA) 2012 grades of recommendation
    • strength of recommendation
      • Strong recommendation - desirable effects clearly outweigh undesirable effects, or vice versa
      • Weak recommendation - desirable effects closely balanced with undesirable effects, or (with low- or very low-quality evidence) uncertainty in estimates of desirable effects, harms, and burden so they may be closely balanced
    • quality of evidence
      • High-quality evidence - consistent evidence from well-performed randomized controlled trials (RCTs) or exceptionally strong evidence from unbiased observational studies
      • Moderate-quality evidence - evidence from RCTs with important limitations (inconsistent results, methodologic flaws, indirect, or imprecise) or exceptionally strong evidence from unbiased observational studies
      • Low-quality evidence - evidence for ≥ 1 critical outcome from observational studies, RCTs with serious flaws, or indirect evidence
      • Very low-quality evidence - evidence for ≥ 1 critical outcome from unsystematic clinical observations or very indirect evidence
    • Reference - IDSA 2012 clinical practice guideline on diagnosis and treatment of diabetic foot infections (22619242Clin Infect Dis 2012 Jun;54(12):e132OpenInNewfull-textOpenInNew)
  • Infectious Diseases Society of America (IDSA) 2011 grades of recommendation
    • strength of recommendations
      • Grade A - good evidence to support a recommendation for or against use
      • Grade B - moderate evidence to support a recommendation for or against use
      • Grade C - poor evidence to support a recommendation
    • quality of evidence
      • Level I - evidence from > 1 properly randomized, controlled trial
      • Level II - evidence from > 1 well-designed clinical trial, without randomization; from cohort or case-controlled analytic studies (preferably from > 1 center); from multiple time series; or from dramatic results from uncontrolled experiments
      • Level III - evidence from opinions of authorities, based on clinical experience, descriptive studies, or reports of expert committees
    • Reference - IDSA clinical practice guideline on treatment of methicillin-resistant Staphylococcus aureus infections in adults and children (21208910Clin Infect Dis 2011 Feb 1;52(3):e18OpenInNewfull-textOpenInNew)

Synthesized Recommendation Grading System for DynaMed

  • DynaMed systematically monitors clinical evidence to continuously provide a synthesis of the most valid relevant evidence to support clinical decision-making (see 7-Step Evidence-Based MethodologyOpenInNew).
  • Guideline recommendations summarized in the body of a DynaMed topic are provided with the recommendation grading system used in the original guideline(s), and allow DynaMed users to quickly see where guidelines agree and where guidelines differ from each other and from the current evidence.
  • In DynaMed (DM), we synthesize the current evidence, current guidelines from leading authorities, and clinical expertise to provide recommendations to support clinical decision-making in the Overview & Recommendations section.
  • We use the Grading of Recommendations Assessment, Development and Evaluation (GRADE)OpenInNew to classify synthesized recommendations as Strong or Weak.
    • Strong recommendations are used when, based on the available evidence, clinicians (without conflicts of interest) consistently have a high degree of confidence that the desirable consequences (health benefits, decreased costs and burdens) outweigh the undesirable consequences (harms, costs, burdens).
    • Weak recommendations are used when, based on the available evidence, clinicians believe that desirable and undesirable consequences are finely balanced, or appreciable uncertainty exists about the magnitude of expected consequences (benefits and harms). Weak recommendations are used when clinicians disagree in judgments of relative benefit and harm, or have limited confidence in their judgments. Weak recommendations are also used when the range of patient values and preferences suggests that informed patients are likely to make different choices.
  • DynaMed (DM) synthesized recommendations (in the Overview & Recommendations section) are determined with a systematic methodology:
    • Recommendations are initially drafted by clinical editors (including ≥ 1 with methodological expertise and ≥ 1 with content domain expertise) aware of the best current evidence for benefits and harms, and the recommendations from guidelines.
    • Recommendations are phrased to match the strength of recommendation. Strong recommendations use "should do" phrasing, or phrasing implying an expectation to perform the recommended action for most patients. Weak recommendations use "consider" or "suggested" phrasing.
    • Recommendations are explicitly labeled as Strong recommendations or Weak recommendations when a qualified group has explicitly deliberated on making such a recommendation. Group deliberation may occur during guideline development. When group deliberation occurs through DynaMed-initiated groups:
      • Clinical questions will be formulated using the PICO (Population, Intervention, Comparison, Outcome) framework for all outcomes of interest specific to the recommendation to be developed.
      • Systematic searches will be conducted for any clinical questions where systematic searches were not already completed through DynaMed content development.
      • Evidence will be summarized for recommendation panel review including for each outcome, the relative importance of the outcome, the estimated effects comparing intervention and comparison, the sample size, and the overall quality rating for the body of evidence.
      • Recommendation panel members will be selected to include at least 3 members that together have sufficient clinical expertise for the subject(s) pertinent to the recommendation, methodological expertise for the evidence being considered, and experience with guideline development.
      • All recommendation panel members must disclose any potential conflicts of interest (professional, intellectual, and financial), and will not be included for the specific panel if a significant conflict exists for the recommendation in question.
      • Panel members will make Strong recommendations if and only if there is consistent agreement in a high confidence in the likelihood that desirable consequences outweigh undesirable consequences across the majority of expected patient values and preferences. Panel members will make Weak recommendations if there is limited confidence (or inconsistent assessment or dissenting opinions) that desirable consequences outweigh undesirable consequences across the majority of expected patient values and preferences. No recommendation will be made if there is insufficient confidence to make a recommendation.
      • All steps in this process (including evidence summaries which were shared with the panel, and identification of panel members) will be transparent and accessible in support of the recommendation.
    • Recommendations are verified by ≥ 1 editor with methodological expertise, not involved in recommendation drafting or development, with explicit confirmation that Strong recommendations are adequately supported.
    • Recommendations are published only after consensus is established with agreement in phrasing and strength of recommendation by all editors.
    • If consensus cannot be reached then the recommendation can be published with a notation of "dissenting commentary" and the dissenting commentary is included in the topic details.
    • If recommendations are questioned during peer review or post publication by a qualified individual, or reevaluation is warranted based on new information detected through systematic literature surveillance, the recommendation is subject to additional internal review.

DynaMed Editorial Process

Special acknowledgements

On behalf of the American College of Physicians
  • Barbara Turner, MD, MSEd, MACP, ACP Deputy Editor, Clinical Decision Resource, as part of the ACP-EBSCO Health collaboration, managed the ACP peer review of the Overview and Recommendations section and related clinical content in this topic.
  • DynaMed topics are written and edited through the collaborative efforts of the above individuals. Deputy Editors, Section Editors, and Topic Editors are active in clinical or academic medical practice. Recommendations Editors are actively involved in development and/or evaluation of guidelines.
  • Editorial Team role definitions
    Topic Editors define the scope and focus of each topic by formulating a set of clinical questions and suggesting important guidelines, clinical trials, and other data to be addressed within each topic. Topic Editors also serve as consultants for the internal DynaMed Editorial Team during the writing and editing process, and review the final topic drafts prior to publication.
    Section Editors have similar responsibilities to Topic Editors but have a broader role that includes the review of multiple topics, oversight of Topic Editors, and systematic surveillance of the medical literature.
    Recommendations Editors provide explicit review of DynaMed Overview and Recommendations sections to ensure that all recommendations are sound, supported, and evidence-based. This process is described in "Synthesized Recommendation Grading."
    Deputy Editors are employees of DynaMed and oversee DynaMed internal publishing groups. Each is responsible for all content published within that group, including supervising topic development at all stages of the writing and editing process, final review of all topics prior to publication, and direction of an internal team.
  • The Association of Medical Microbiology and Infectious Disease Canada provides review for the incorporation of Choosing Wisely Canada recommendations.

How to cite

National Library of Medicine, or "Vancouver style" (International Committee of Medical Journal Editors):

  • DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995 - . Record No. T116047, Osteomyelitis; [updated 2018 Nov 30, cited place cited date here]. Available from https://www.dynamed.com/topics/dmp~AN~T116047. Registration and login required.
  • KeyboardArrowRight

    Overview and Recommendations

    • Background

    • Evaluation

    • Management

  • Related Summaries

  • KeyboardArrowRight

    General Information

    • Description

    • Definitions

    • Types

  • KeyboardArrowRight

    Epidemiology

    • Incidence/Prevalence

    • Risk factors

  • KeyboardArrowRight

    Etiology and Pathogenesis

    • Causes

    • Pathogenesis

  • KeyboardArrowRight

    History and Physical

    • Clinical presentation

    • History

    • KeyboardArrowRight

      Physical

      • General physical

      • Musculoskeletal

      • Vascular

      • Neuro

  • KeyboardArrowRight

    Diagnosis

    • Making the diagnosis

    • Differential diagnosis

    • Testing overview

    • Blood tests

    • KeyboardArrowRight

      Imaging studies

      • Approach to imaging

      • X-ray

      • MRI

      • CT

      • Bone scan

      • White blood cell scan

      • PET

    • Biopsy and culture

  • KeyboardArrowRight

    Management

    • Management overview

    • KeyboardArrowRight

      Medications

      • KeyboardArrowRight

        Antibiotic therapy

        • Selection of antibiotic regimen

        • Efficacy

        • Route of administration

        • Treatment duration

        • Suppressive antibiotic therapy

    • Surgery and procedures

    • Consultation and referral

    • Follow-up

  • KeyboardArrowRight

    Complications and Prognosis

    • Complications

    • Prognosis

  • Prevention and Screening

  • KeyboardArrowRight

    Quality Improvement

    • Choosing Wisely Canada

  • KeyboardArrowRight

    Guidelines and Resources

    • KeyboardArrowRight

      Guidelines

      • United States guidelines

      • European guidelines

      • Asian guidelines

      • Central and South American guidelines

      • Australian and New Zealand guidelines

    • Review articles

    • MEDLINE search

  • Patient Information

  • KeyboardArrowRight

    ICD Codes

    • ICD-10 codes

  • KeyboardArrowRight

    References

    • General References Used

    • Recommendation Grading Systems Used

    • Synthesized Recommendation Grading System for DynaMed

    • DynaMed Editorial Process

    • Special acknowledgements

    • How to cite

Topic Editor
Paritosh Prasad MD
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Affiliations

Assistant Professor of Pulmonary Diseases and Critical Care, University of Rochester School of Medicine; New York, United States

Conflicts of Interest

Dr. Prasad declares no relevant financial conflicts of interest.

Recommendations Editor
Esther Jolanda van Zuuren MD
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Affiliations

Head of Allergy, Dermatology, and Venereology, Leiden University Medical Centre; Netherlands

Conflicts of Interest

Dr. van Zuuren declares no relevant financial conflicts of interest.

Deputy Editor
Vito Iacoviello MD, FIDSA
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Affiliations

Deputy Editor of Infectious Diseases, Immunology and Rheumatology, Dynamed; Massachusetts, United States; Assistant Professor of Medicine, Harvard Medical School; Massachusetts, United States; Chief of the Division of Infectious Diseases, Mount Auburn Hospital; Massachusetts, United States

Conflicts of Interest

Dr. Iacoviello declares no relevant financial conflicts of interest.

ACP Reviewer
James C. Pile MD
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Affiliations

Staff Physician, Division of Hospital Medicine, Program Director, Internal Medicine Residency, Case Western Reserve University/MetroHealth Medical Center; Ohio, United States; Associate Professor of Medicine, Case Western Reserve University School of Medicine; Ohio, United States

Conflicts of Interest

Dr. Pile declares no relevant financial conflicts of interest.

Produced in collaboration with American College of Physicians

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Osteomyelitis of the Foot

Osteomyelitis of the Foot

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