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CME

Bisphosphonates for Treatment and Prevention of Osteoporosis

General Information

Description

  • bisphosphonates are 1 pharmacological option used for prevention and treatment of osteoporosis with the goal of inhibiting bone resorption, increasing bone strength, and decreasing risk of osteoporosis fractures1,2,3
  • other options for prevention and treatment of osteoporosis include1,2,3
    • hormonal replacement therapy
    • estrogen agonist/antagonist (such as raloxifene)
    • receptor activator of nuclear factor kappa-B (RANK) inhibitor (denosumab)
    • parathyroid hormone 1-34 (teriparatide) or parathyroid hormone related peptide (PTHrP[1-34]) analog (abaloparatide)
    • see Medications in Osteoporosis for additional information
  • patients with osteoporosis or at risk for osteoporosis should be advised on1,3
    • risk of osteoporosis-related fractures
    • decision to initiate bisphosphonates, which should be based on clinical judgment and patient preferences
    • importance of calcium, vitamin D, and exercise as part of any treatment program for osteoporosis
  • an effective treatment reduces fracture risk, but does not necessarily eliminate fracture risk

Definitions and classifications

  • osteoporosis - generalized skeletal disorder characterized by low bone density, deterioration of bone quality, and compromised bone strength, often leading to fragility fracture due to excessive bone loading from a fall or certain activities of daily living1
  • fragility (low trauma) fracture - fracture from minor trauma (for instance, fall from standing height or less) or that occurs spontaneously (28293453Eur J Rheumatol 2017 Mar;4(1):46full-text)
  • z-score - bone mineral density (BMD) score representing number of standard deviations above or below mean value for age-, race-, ethnicity-, and sex-matched persons4
  • T-score - BMD score representing number of standard deviations above or below mean for normal young white women4
  • classification of bone health according to T-score for postmenopausal women and men ≥ 50 years old (1, mnh26280231pcxh108836713pmdc26280231pAm Fam Physician 2015 Aug 15;92(4):261full-text)
    Classification BMD T-score
    NormalWithin 1 SD of mean level for young-adult reference population T-score ≥ -1.0
    Low bone mass (osteopenia)Between 1 and 2.5 SD below mean level for young-adult reference populationT-score between -1 and -2.5
    Osteoporosis ≥ 2.5 SD below mean level for young-adult reference population T-score ≤ -2.5
    Severe or established osteoporosis ≥ 2.5 SD below mean level for young-adult reference population plus fragility fractures T-score ≤ -2.5 plus ≥ 1 fracture
    Abbreviations: BMD, bone mineral density; SD, standard deviation.
  • Fracture Risk Assessment (FRAX) - risk calculator used to estimate 10-year probability of hip fracture and 10-year probability of major osteoporosis fracture (such as clinical vertebral, hip, proximal humerus, and distal forearm fractures), based on femoral neck BMD (if available) and presence of clinical risk factors; intended for postmenopausal women and men ≥ 50 years old1,4
  • treatment failure - significant reduction in BMD or recurrent fractures in patient who is compliant to therapy4
  • antiresorptive medications - suppress bone turnover and increase BMD; antiresorptive only medications include

References

General references used

  1. Cosman F, de Beur SJ, LeBoff MS, et al; National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014 Oct;25(10):2359-81full-text, correction can be found in Osteoporos Int 2015 Jul;26(7):2045, commentary can be found in JAMA 2015 Apr 14;313(14):1467
  2. Compston J, Cooper A, Cooper C, et al; National Osteoporosis Guideline Group (NOGG). UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos. 2017 Dec;12(1):43 full-text
  3. Maraka S, Kennel KA. Bisphosphonates for the prevention and treatment of osteoporosis. BMJ. 2015 Sep 2;351:h3783, commentary can be found in BMJ 2015 Nov 4;351:h5868
  4. Camacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2016. Endocr Pract. 2016 Sep 2;22(Suppl 4):1-42

Recommendation grading systems used

  • American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) and American Association of Clinical Endocrinologists/The Obesity Society/American Society for Metabolic & Bariatric Surgery (AACE/TOS/ASMBS) grading recommendations
    • recommendation grade
      • Grade A - evidence from multiple, well-designed, randomized, cohort controlled trials with sufficient statistical power; ≥ 1 conclusive level 1 publications demonstrating benefit greater than risk
      • Grade B - evidence from ≥ 1 well-designed clinical trial, cohort- or case-controlled analytic study, or meta-analysis; no conclusive level 1 publication; ≥ 1 conclusive level 2 publications demonstrating benefit greater than risk
      • Grade C - evidence based on clinical experience, descriptive studies, or expert consensus opinion; no conclusive level 1 or 2 publications; ≥ 1 conclusive level 3 publications demonstrating benefit greater than risk, no risk, or no benefit
      • Grade D - no conclusive level 1, 2, or 3 publications demonstrating risk greater than benefit; conclusive level 1, 2, or 3 publication demonstrating risk is greater than benefit
    • Best evidence level (BEL)
      • BEL 1 - strong evidence
        • subject factor impact
          • none - grade A
          • negative - grade B
      • BEL 2 - intermediate evidence
        • subject factor impact
          • positive - grade A
          • none - grade B
          • negative - grade C
      • BEL 3 - weak evidence
        • subject factor impact
          • positive - grade B
          • none - grade C
          • negative - grade D
      • BEL 4 - no evidence
        • subject factor impact
          • positive - grade C
          • none - grade D
    • References -
  • American College of Rheumatology (ACR) recommendation system
    • Strong recommendation - confidence that desirable effects of recommendation outweigh undesirable effects (or vice versa), course of action would apply to all or almost all patients
    • Conditional recommendation - desirable effects of recommendation probably outweigh undesirable effects, course of action would apply to majority of the patients
    • Good practice recommendation - benefits of proceeding with guidance outweigh the harms, but supporting evidence is indirect
    • Reference - ACR guideline for prevention and treatment of glucocorticoid-induced osteoporosis (cxh124315756t pmdc28585373pArthritis Rheumatol 2017 Aug;69(8):1521)
  • Endocrine Society uses Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system
    • strength of recommendation
      • Strong recommendation - guideline panel members have high confidence that desirable effects of recommendation outweigh undesirable effects (or vice versa)
      • Weak recommendation - guideline panel members conclude with less confidence that desirable effects of recommendation probably outweigh undesirable effects, or benefits and harms are finely balanced, or appreciable uncertainty
    • quality of evidence
      • High-quality evidence - consistent evidence from well-performed randomized controlled trials, or exceptionally strong evidence from unbiased observational studies
      • Moderate-quality evidence - randomized controlled trials with important limitations (inconsistent results, methodological flaws, indirect or imprecise evidence), or unusually strong evidence from unbiased observational studies
      • Low-quality evidence - ≥ 1 critical outcome from observational studies, randomized controlled trials with serious flaws, or indirect evidence
      • Very low-quality evidence - ≥ 1 of the critical outcomes from unsystematic clinical observations or very indirect evidence
  • National Osteoporosis Guideline Group (NOGG) grading recommendations
    • levels of evidence for studies of intervention
      • Ia - meta-analysis of randomized controlled trials (RCT)
      • Ib - from ≥ 1 RCT
      • IIa - from ≥ 1 well-designed controlled study without randomization
      • IIb - from ≥ 1 well-designed quasi-experimental study
      • III - from well-designed nonexperimental descriptive studies (comparative studies, correlation studies, case-control studies)
      • IV - reports from expert committees, opinions, or clinical experience
    • quality of recommendations
      • Grade A - evidence levels Ia and Ib; validated by use as inclusion criteria in RCT
      • Grade B - evidence levels IIa, IIb, III; does not adversely affect fracture outcomes in randomized controlled trials
      • Grace C - evidence level IV; untested or adversely affect intervention outcomes
  • Osteoporosis Canada (OC) level of evidence criteria
    • treatment and intervention
      • 1+ - systematic overview of meta-analysis of randomized controlled trials (RCTs)
      • 1 - RCT with adequate power
      • 2+ - systematic overview or meta-analysis of level 2 RCTs
      • 2 - randomized controlled trial that does not meet level  1  criteria
      • 3 - nonrandomized controlled trial or cohort study
      • 4 - before/after study, cohort study with noncontemporaneous controls, case-control study
      • 5 - case series without controls
      • 6 - case report or case series < 10 patients
    • grades of recommendation
      • Grade A - support level 1 or 1+ evidence plus consensus
      • Grade B - support level 2 or 2+ evidence plus consensus
      • Grade C - support level 3 evidence plus consensus
      • Grade D - any lower level of evidence supported by consensus
    • Reference - 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada (mnh20940232pmdc20940232pCMAJ 2010 Nov 23;182(17):1864)

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Special acknowledgements

On behalf of the American College of Physicians
  • Barbara Turner, MD, MSEd, MACP, ACP Deputy Editor, Clinical Decision Resource, as part of the ACP-EBSCO Health collaboration, managed the ACP peer review of the Overview and Recommendations section and related clinical content in this topic.
Choosing Wisely Canada acknowledges dissemination of their recommendations through DynaMed Plus to reach the point of clinical decision-making.
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How to cite

National Library of Medicine, or "Vancouver style" (International Committee of Medical Journal Editors):

  • DynaMed [Internet]. Ipswich (MA): EBSCO Information Services. 1995 - . Record No. T900139, Bisphosphonates for Treatment and Prevention of Osteoporosis; [updated 2018 Dec 03, cited place cited date here]. Available from https://www.dynamed.com/topics/dmp~AN~T900139. Registration and login required.

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